Thanks for sharing our paper, @Helios_Movement! Shoutout to Dr. Renee Nelson who was a med student on her research rotation with me at the time and took on this project! Link to the full paper: https://www.mdpi.com/2075-4426/13/11/1562

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28 Oct 2026 0 comments

Thanks for sharing our paper, @Helios_Movement! Shoutout to Dr. Renee Nelson who was a med student on her research rotation with me at the time and took on this project!

Link to the full paper:
mdpi.com/2075-4426/13/11/156…

Neuropsychiatric Manifestations of Mast Cell Activation Syndrome and Response to Mast-Cell-Directed...

Mast cell activation syndrome (MCAS) is an immune disease with an estimated prevalence of 17%. Mast cell chemical mediators lead to heterogeneous multisystemic inflammatory and allergic manifestati...

George Ferman (@Helios_Movement)

This is a small case series of patients with refractory neuropsychiatric disorders such as depression, anxiety, OCD, ADHD and more, who experienced significant improvement after subsequent diagnosis and treatment of MCAS.

While the average person still thinks that histamine for example is just something related to allergies, let’s not forget that histamine acts as a neurotransmitter in the brain, influencing things such as arousal, attention, mood, sleep, and motivation.

So when levels build up it can create:

-Restlessness and physical + mental hyperactivity

-Difficulty concentrating, brain fog, inattention

-Irritability, impulsivity, or agitation

-Sleep disturbances (insomnia or poor sleep quality)

-Anxiety or sensory sensitivities

-Hyper arousal

-Racing thoughts, anxiety/panic, or restlessness

-Insomnia or disrupted sleep cycles (common in manic phases)

-Depressive symptoms (fatigue, brain fog, low motivation) during crashes

-Emotional lability or energy fluctuations

Of course, we don’t pull all these out of our asses.

There are more reports noting that histamine flares can mimic manic/depressive episodes, and MCAS patients sometimes receive initial bipolar diagnoses.

— http://x.com/Helios_Movement/status/2114347397736198483#m