Serotonergic Modulation in Absence Epilepsy: The Role of Thalamo-cortical Networks and 5-hydroxytryptamine Receptors

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29 Oct 2026 0 comments

Absence epilepsy is characterized by brief nonconvulsive seizures and generalized spike-and-wave discharges (SWDs) generated within distributed cortico-thalamo-cortical networks. Although the roles of T-type calcium channels, GABAergic inhibition, and network synchronization are well established, serotonergic modulation of these circuits remains incompletely defined. This review integrates evidence from genetic and pharmacological animal models, receptor signaling and distribution studies, human...