Beyond seizures: the hidden burden of developmental epileptic encephalopathies

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29 Oct 2026 0 comments

Developmental and epileptic encephalopathies (DEEs) are a group of severe childhood-onset disorders characterized by drug-resistant epilepsy and a broad spectrum of neurodevelopmental, behavioral, psychiatric, and systemic manifestations. Although seizure control has traditionally been the primary therapeutic goal, growing evidence indicates that non-seizure manifestations often represent the main determinants of long-term disability, quality of life, and caregiver burden. This review highlights...