Amygdala-HPA axis interactions in temporal lobe epilepsy with anxiety comorbidity

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30 Oct 2026 0 comments

Temporal lobe epilepsy (TLE) is the most common type of focal epilepsy and is frequently associated with various psychiatric and psychological comorbidities, among which anxiety is one of the most common and clinically significant symptoms. Anxiety not only significantly reduces patients' quality of life and treatment adherence but may also increase susceptibility to seizures, thereby exacerbating the burden of the disease. However, the neurobiological mechanisms underlying the comorbidity of...