Cerebral venous thrombosis during pregnancy and the puerperium in the setting of hyperhomocysteinemia and methylenetetrahydrofolate reductase c.677 C > T polymorphism

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30 Oct 2026 0 comments

CONCLUSIONS: In this case series, HHcy was observed in all four patients with pregnancy- or puerperium-associated CVT and the MTHFR c.677 C > T polymorphism, while higher homocysteine levels and more severe neurological manifestations were observed in the two TT carriers. These observations are exploratory and hypothesis-generating and do not support changes in routine homocysteine screening, MTHFR genotyping, or standard CVT management. Larger prospective multicenter studies are required to...