Developmental changes in activity-dependent plasticity of maturation-related neuronal phenotypes

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30 Oct 2026 0 comments

Immaturity of neurons in the adult hippocampal dentate gyrus (DG) has been implicated in the pathophysiology of neuropsychiatric disorders. Pseudo-immaturity of DG neurons can be induced by neuronal hyperexcitation in adulthood. This "dematuration," a reversal of maturation, could lead to aberrant neuronal maturation, if activated during development. However, it has not been directly tested whether dematuration can be induced in developing neurons. In the present study, we examined the effect of...