Hypothalamic hamartoma in a child with Pallister-Hall syndrome: Report of a rare lesion successfully managed with multidisciplinary approach

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31 Oct 2026 0 comments

Hypothalamic hamartomas (HH) are rare, benign malformations of the hypothalamus, often presenting with gelastic seizures, developmental delays, and endocrine abnormalities. These lesions can disrupt normal hypothalamic function, resulting in gelastic seizures, endocrine abnormalities, and neurocognitive or behavioral disturbances. HHs may be associated with syndromic conditions like Pallister-Hall syndrome. We report the case of a 2-year-old female with gelastic seizures, syndactyly,...