A novel coumarin-derived Schiff base ligand suppresses TLR-NFκB signalling and oxidative stress in vitro, and exhibits anticonvulsant activity in vivo

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31 Oct 2026 0 comments

Neuroinflammation is a primary hallmark of chronic neurodegenerative diseases and is also implicated in poor outcomes following acute trauma and brain injury. Neuroinflammation arises largely from dysregulated activation of microglia, which disrupts neuronal function and promotes degradation of the blood-brain barrier. This, in turn, accelerates progressive neurotoxicity that characterises these conditions. Most neurodegenerative diseases are marked by a paucity of disease-modifying therapies,...