MCH-02, a synthetic macamide analog with in vitro FAAH-inhibitory activity, modulates hippocampal endocannabinoid system and BK channel expression without preventing PTZ-induced progressive seizure susceptibility in rats

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31 Oct 2026 0 comments

Epilepsy remains a major neurological disorder, with about 30% of patients showing drug resistance despite the availability of multiple antiseizure medications. The endocannabinoid system (ECS) has emerged as a promising therapeutic target due to its role in regulating neuronal excitability. This study examined the effects of a new macamide-derived fatty acid amide hydrolase (FAAH) inhibitor, N-(8Z-heptadecen-1-yl)-O-(3-pyridylmethyl) carbamate (MCH-02), on seizure development, cognition, and...