Therapeutic Potential of Formononetin in Drug-Resistant Epilepsy: Evidence from a Rotenone-PTZ-Lamotrigine Mouse Model

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01 Nov 2026 0 comments

Drug-resistant epilepsy (DRE) affects nearly one-third of individuals with epilepsy and remains a major therapeutic challenge despite the availability of multiple antiseizure medications. Mitochondrial dysfunction and chronic neuroinflammation, particularly NLRP3 inflammasome activation, are increasingly recognized as key contributors to pharmacoresistance. Formononetin, a plant-derived isoflavone, has shown anticonvulsant and neuroprotective effects in pentylenetetrazol (PTZ) kindled mice by...