Expression of Tachykinin 2/Neurokinin B and Neuropeptide Y and the Functional Contribution of Neuropeptide Y in the Mouse Dentate Gyrus following Repeated Electroconvulsive Seizure

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02 Nov 2026 0 comments

Electroconvulsive therapy is an effective treatment option for major depression. Studies using rodent electroconvulsive seizure (ECS) models have suggested that the dentate gyrus (DG) of the hippocampal formation is critically involved and that ECS induces robust transcriptomic changes in the DG. Although previous studies have suggested that the expression of two neuropeptide genes, Tachykinin 2 (TAC2) and neuropeptide Y (Npy), is induced by repeated ECS in the DG, the temporal and spatial...