Proton-pump inhibitor-induced severe hypomagnesemia presenting with seizure and functional hypoparathyroidism: A diagnostic challenge in long-term acid suppression therapy

Aggregator

02 Nov 2026 0 comments

Proton-pump inhibitors (PPIs) are popular drugs used to treat acid-related disorders. The PPIs, though effective and relatively safe, have been linked to clinically significant hypomagnesemia with long-term use, which causes potentially life-threatening complications. A 68-year-old male with an 8-year history of omeprazole 40 mg/day use presented with a generalized tonic-clonic seizure and neuromuscular irritability. Laboratory tests showed severe hypomagnesemia (0.32 mmol/L), hypocalcemia...