Seizures in mesial temporal lobe epilepsy (MTLE) can spread to the insular cortex (IC) due to its connections with hippocampal and para-hippocampal areas. The contribution of specific cell types in the IC to ictogenesis remains however unclear. Therefore, we analyzed in the pilocarpine model of MTLE the effects of optogenetic activation of IC parvalbumin (PV)-positive interneurons on CA3 field activity. Light pulses were delivered at 0.5 Hz (300 s ON, 600 s OFF) in IC, between day 4 and 14 after...
Source: PubMed - functional seizures
·Published 03 Nov 2026 ·Imported 03 Nov 2026
Relevancy: Not reviewed
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