Cerebrospinal Fluid GAD65-Antibody Levels Accurately Identify Relevant Neurological Diseases

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03 Nov 2026 0 comments

Retrospective cohort study to investigate which factors most reliably distinguish incidental GAD65-antibodies (iGAD65) from true GAD65-antibody neurological disease (tGAD65). 167 adults with positive serum and CSF GAD65-antibodies (> 0.02 nmol/L by radioimmunoassay) were classified as tGAD65 or iGAD65, with diagnostic performance of paraclinical parameters compared in discovery and validation cohorts. CSF GAD65-antibody titers ≥ 1 nmol/L performed best in discovery (AUC 0.956) and validation...