Neural circuits, cognition, and behavior in diffuse glioma

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03 Nov 2026 0 comments

Diffuse gliomas arise within and become functionally integrated into neural circuits, establishing bidirectional interactions between malignant cells and the surrounding brain. Neuronal activity promotes glioma growth and progression, while glioma cells remodel the excitability, connectivity, and functional organization of the neural circuits they infiltrate. Pathological excitation-inhibition imbalance can impair cortical information processing, while tumor infiltration simultaneously disrupts,...