Case Report: Longitudinal evaluation of cerebrospinal fluid Alzheimer's disease core biomarkers in a case of refractory late-onset epilepsy of unknown etiology

Aggregator

03 Nov 2026 0 comments

In recent years, late-onset epilepsy of unknown etiology (LOEU) has increasingly been recognized as a risk factor for Alzheimer's disease (AD) and other forms of dementia. We present a case of refractory LOEU with progressive cognitive decline, longitudinally evaluated over more than 20 years using neuropsychological tests, cerebrospinal fluid (CSF) AD core biomarkers (Aβ42/40 ratio, p-tau), electroencephalography, and neuroimaging. The CSF AD core biomarkers were consistently positive,...