Brezosiran Demonstrates Mutant Huntingtin Reduction in Phase 1b Huntington Disease Study

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Alnylam Pharmaceuticals reported initial Phase 1b findings showing brezosiran reduced cerebrospinal fluid mutant huntingtin levels by a mean of 60% to 64% at 3 months, with plans for a pivotal study in 2027.

Source: NeurologyLive Published 03 Nov 2026 Imported 04 Nov 2026 Relevancy: Not reviewed

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