Full title: From neural excitability to volatile signatures: A mechanistic hypothesis for pre-ictal volatile organic compound signatures in epilepsy

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04 Nov 2026 0 comments

OBJECTIVE: Seizure unpredictability remains a major contributor to morbidity in epilepsy, and biomarkers capable of identifying pre-ictal states are critically needed. Volatile organic compounds (VOCs) have emerged as potential noninvasive indicators of seizure susceptibility, yet the biological mechanisms linking pre-ictal neural states to peripheral volatile signatures remain poorly understood.