Investigating cardiorespiratory fitness, cerebral blood flow, and brain metabolism in epilepsy

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04 Nov 2026 0 comments

INTRODUCTION: Idiopathic generalized epilepsies (IGEs) are characterized by seizures that propagate through widespread thalamocortical networks including the anterior cingulate cortex (ACC). Poor cardiorespiratory fitness may exacerbate neurovascular and metabolic vulnerability including heightened susceptibility to sudden unexpected death in epilepsy. We aimed to examine cardiorespiratory fitness, regional cerebral blood flow (CBF), and metabolite concentrations in patients with IGEs (PwIGEs)...