Neuromodulation Therapies for Depression: Current Status and Future Directions

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05 Nov 2026 0 comments

Major depressive disorder is a leading cause of disability worldwide, and many patients fail to achieve sustained remission with first-line pharmacotherapy or psychotherapy. This unmet need has traditionally been framed as treatment-resistant depression (TRD), defined by an inadequate response to antidepressant treatment. Within this context, neuromodulation has assumed an increasingly important role by providing mechanistically distinct interventions when medication-based approaches are...