Sex differences in post-traumatic epileptogenesis and neurological dysfunction following traumatic brain injury

Aggregator

06 Nov 2026 0 comments

Post-traumatic epilepsy (PTE) is a disabling long-term consequence of traumatic brain injury (TBI), but the role of biological sex on epileptogenesis and recovery remains unclear. Here, we comprehensively characterized chronic PTE development and neurological outcomes in adult male and female mice after severe TBI by controlled cortical impact. Animals underwent continuous video-EEG monitoring for 120 days, serial behavioral, motor, and cognitive testing, and terminal histological assessment of...