VAMP2-mediated PPAR signaling modulates mitophagy and inflammatory responses in Mg 2+ -free induced HT22 neuronal cells

06 Nov 2026 0 comments

CONCLUSION: A novel VAMP2-PPAR-mitophagy axis was identified in seizure-injured neurons, which maintains mitochondrial integrity and alleviates neuronal damage. Targeting the crosstalk between vesicle trafficking and nuclear receptor signaling may provide potential therapeutic ideas for hyperexcitability-related neurodegenerative disorders.

Source: PubMed - functional seizures Published 05 Nov 2026 Imported 06 Nov 2026 Relevancy: Not reviewed

Read the article

Comments

No comments yet.

Unrestricted

All comments are reviewed before being published. Most comments are approved unless they are clearly inappropriate or unsafe.

Comments

Leave a comment