Effects of Pantoprazole on PTZ-Kindling Progression and Associated Neuroinflammatory and Endoplasmic Reticulum Stress Responses in Rats

Aggregator

06 Nov 2026 0 comments

Epileptogenesis is characterized by complex molecular changes, including neuroinflammation, endoplasmic reticulum (ER) stress, and apoptosis, contributing to seizures and associated cognitive and behavioral impairments. Pantoprazole, a proton pump inhibitor, has demonstrated anti-inflammatory and neuroprotective properties. This study investigated its effects on PTZ-kindling progression and associated molecular alterations in a pentylenetetrazole (PTZ)-induced rat model. Adult male Wistar albino...