Progressive Multifocal Leukoencephalopathy Misdiagnosed as a Stroke

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06 Nov 2026 0 comments

Progressive multifocal leukoencephalopathy (PML) is rare and can be challenging to diagnose. Symptoms can be varied and can mimic stroke phenotypes. Physicians must hold a high index of suspicion in patients with significant PML risk factors (including HIV/AIDS, immunosuppression, lymphoproliferative malignancies and chemotherapy/monoclonal antibody therapies) presenting with progressive neurological symptoms. Here, we describe a 63-year-old man who presented with left-sided weakness, apraxia...