Resting-State Functional Metrics Associated with Seizure Recurrence After Antiseizure Medication Withdrawal

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06 Nov 2026 0 comments

Antiseizure medication (ASM) withdrawal after sustained seizure freedom requires a balanced estimate of recurrence risk, yet objective imaging correlates remain uncertain. This prospective observational protocol compared prewithdrawal resting-state functional magnetic resonance imaging (fMRI) in 30 patients with epilepsy and 22 healthy controls (HC). All patients completed 12 months of follow-up after complete withdrawal; 16 developed recurrence (RG) and 14 remained seizure-free (NRG)....