Epitope-dependent acute inhibition and potentiation of N-methyl-d-aspartate receptors by GluN1 autoantibodies

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06 Nov 2026 0 comments

Transfer of autoantibodies targeting ionotropic N-methyl-d-aspartate (NMDA) receptors from patients with autoimmune encephalitis to mice induces characteristic disease signs. The long-term effects of pathogenic antibodies include immunoglobulin G (IgG)-induced cross-linking and receptor internalization. We investigated the direct and immediate impact of two specific pathogenic patient-derived monoclonal autoantibodies (IgG #003-102 and #007-168) on NMDA receptor (NMDAR) function. We performed...