Pilocarpine disrupts spontaneous rhythmic inhibitory bursting in the basolateral amygdala, promoting a transition to hyperexcitability

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07 Nov 2026 0 comments

The view that seizures arise from an imbalance between excitatory and inhibitory activity, favoring excessive excitation, provides a valid but simplified description of the synaptic interactions underlying seizure initiation. Synchronous, rhythmic activity of inhibitory interneurons is known for imposing order in the activity of neuronal networks, often shaping or giving rise to local and long-range oscillations; disruption of rhythmic inhibitory activity could contribute to network...