A Human iPSC-Derived Neuron and Glioma Culture Model Reveals Increased Neuronal Excitability and Loss of GABAergic Inhibition

Aggregator

08 Nov 2026 0 comments

Gliomas engage in bidirectional interactions with neural circuits, driving hyperexcitability, disruption of excitatory-inhibitory balance, and tumor-associated seizures. Human in vitro models that enable functional interrogation of tumor-induced changes in glutamatergic-GABAergic neuronal crosstalk remain limited. We established a defined human induced pluripotent stem cell (iPSC)-derived culture comprising of glutamatergic neurons, GABAergic neurons, and astrocytes with and without glioma...