Chemogenetic activation of parvalbumin interneurons in the piriform cortex alleviates hippocampal focal seizures

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10 Nov 2026 0 comments

OBJECTIVE: The anterior piriform cortex (APC) is a limbic area closely associated with temporal lobe epilepsy (TLE) but is understudied. Our previous study demonstrated that in the APC, parvalbumin-expressing (PV^(+)) interneurons provide strong inhibition and help maintain excitation-inhibition balance. Here, we examined whether and how APC^(PV) neurons can ameliorate seizure symptoms in TLE.