Evaluation of factors affecting therapeutic levetiracetam drug levels in intensive care unit patients: a retrospective study

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11 Nov 2026 0 comments

CONCLUSION: LEV concentrations showed substantial variability in ICU patients and were independently associated with renal function, LEV dose, indication, and discharge status. However, serum LEV concentration did not discriminate seizure occurrence. These findings support individualized interpretation of LEV TDM results, particularly at the extremes of renal function, but do not demonstrate that achieving the predefined reference range improves seizure control or clinical outcomes.