Optimization and Characterization of a Guinea Pig Model of Diisopropylfluorophosphate-Induced Status Epilepticus, Nitrooxidative Stress, and Neuroinflammation for Therapeutic Evaluation

Aggregator

13 Nov 2026 0 comments

Acute exposure to organophosphate (OP) nerve agents and pesticides induces status epilepticus (SE), nitrooxidative stress, neuroinflammation, and long-term neurological dysfunction. Although rodent models are widely used to study OP-induced neurotoxicity, the guinea pig offers important translational advantages due to its closer similarity to humans in cholinergic physiology and brain organization. The present study aimed to establish and characterize a guinea pig model of...