Delayed-onset seizure after dantrolene-treated malignant hyperthermia in a patient with traumatic brain injury and a pathogenic RYR1 variant: a multiple-hit model

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13 Nov 2026 0 comments

CONCLUSION: In patients with MH and concomitant TBI, delayed seizures may arise primarily from the structural brain injury (cerebral contusions and/or the surgical manipulation of hematoma evacuation), although acute systemic insult (MH) and potential genetic susceptibility (RYR1 variant) could represent additional, unconfirmed contributing factors.Dantrolene should not be relied upon for CNS complications, as its limited CNS penetration and RyR1 selectivity render it ineffective for seizure...