Establishing a functional standard for hiPSC-neural seizure liability MEA assays

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14 Nov 2026 0 comments

The increasing emphasis on New Approach Methodologies (NAMs) to improve the human relevance of safety assessments and reduce reliance on vertebrate animal testing has driven growing interest in in vitro models for neurotoxicity evaluation. The multielectrode array (MEA) assay using human induced pluripotent stem cell (hiPSC)-derived neural cultures has emerged as a promising platform for early detection of drug-induced seizure liability. However, a lack of standardized experimental practices and...