Hypoinsulinemic hypoglycemia with hemihypertrophy in a Filipino infant: management in a resource-limited setting

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17 Oct 2026 0 comments

Persistent infantile hypoglycemia is a medical emergency associated with significant risk of neurological injury. Although most commonly attributed to congenital hyperinsulinism, disorders of impaired insulin signaling with hypoketotic hypoglycemia despite low or undetectable insulin occur in fewer than 1 in 1 000 000 infants worldwide, leading to misdiagnosis and ineffective therapy. We report a Filipino infant with recurrent fasting hypoglycemic seizures and hemihypertrophy. Biochemical...