Acute Status Epilepticus Triggers Long-Term Neurogenic Niche Destabilization That Undermines Cognitive Function in the Excitotoxic FVB/N Hippocampus

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18 Oct 2026 0 comments

The adult hippocampus is highly susceptible to excitotoxic injury, although the extent to which acute seizure episodes dictate long-term cognitive outcomes through neurogenic niche remodeling remains incompletely understood. This study investigated the hypothesis that an isolated episode of sustained status epilepticus (SE) is sufficient to trigger persistent alteration of the adult neurogenic niche, followed by neurostructural and functional discrepancies. Acute SE was induced in young FVB/N...