Prognostic Value of Sudomotor Small-Fiber Function and Large Nerves for Accelerated Renal Decline in Type 2 Diabetes: A Real-World Cohort Study

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20 Oct 2026 0 comments

CONCLUSION: A distinct prognostic dissociation exists within the diabetic neuro-renal axis. Sudomotor small-fiber dysfunction primarily reflects established microvascular impairment, whereas large motor nerve degeneration demonstrates independent prognostic value for future accelerated renal decline. Incorporating this neurofunctional phenotype into traditional clinical models yields substantial individualized risk reclassification, thereby potentially aiding in identifying high-risk...