Pharmacotherapeutic management of chronic pain in joint hypermobility and Ehlers-Danlos syndromes: a clinical perspective

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INTRODUCTION: Joint hypermobility-related pain is an increasingly recognized musculoskeletal pain characterized by mixed pain mechanisms, frequent chronicity, and an incompletely defined natural history. Joint hypermobility-related pain may occur in monogenic Ehlers-Danlos syndromes, but it is more frequently encountered in people with hypermobility spectrum disorders and hypermobile Ehlers-Danlos syndrome, conditions that remain molecularly unresolved.

Source: PubMed - small fiber neuropathy Published 20 Oct 2026 Imported 20 Oct 2026 Relevancy: Not reviewed

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