Resting-state fMRI biomarkers of surgical outcome in temporal lobe epilepsy: Network reorganization, rsfMRI-based prediction models, and cognition - A systematic review

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21 Oct 2026 0 comments

Temporal lobe epilepsy (TLE) is a network disorder extending beyond the structurally defined epileptogenic zone. Resting-state functional MRI (rsfMRI) may provide information on brain network alterations relevant to seizure outcome and cognitive risk after epilepsy surgery. We reviewed rsfMRI studies in TLE surgical cohorts to evaluate postoperative network changes, preoperative predictors of seizure outcome, and associations between functional connectivity and cognition. This systematic review...