Advances in neurological disease models and optimization of the laboratory animal environment for reproducible research

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23 Oct 2026 0 comments

Animal models of neurological diseases have evolved from phenotype-based systems to integrated platforms that link genetics, molecular signaling, synaptic physiology, neural circuits, behavior, and therapeutic responses. Simultaneously, increasingly precise phenotyping has revealed that experimental outcomes are strongly influenced by age, microbiological status, diet, housing, stress, previous experience, health status, and measurement methodology. This review considers these two developments...