Proteolytic Coherence and Trophic Divergence: Region-Specific Mapping of the tPA/PAI-1/uPAR and IGF/IGFBP-5 Responses to Kainic Acid-Induced Seizures

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24 Oct 2026 0 comments

Seizures trigger widespread molecular changes in the brain, but how these responses differ between surviving and degenerating regions remains unclear. Using the intrahippocampal kainic acid model, which is characterized by degeneration of the hippocampus, while the neocortex is less affected, we performed unbiased cytokine array screening and identified two functionally distinct systems that were prominently altered: the proteolytic tPA/PAI-1/uPAR axis and the trophic IGF/IGFBP-5 axis....