It's about time: modeling circadian regulation of cardiac electrophysiology and arrhythmogenesis

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24 Oct 2026 0 comments

Cardiac electrophysiology models resolve processes ranging from millisecond-scale ion-channel gating to hour-scale protein trafficking; yet, most do not explicitly represent circadian time. Consequently, ion-channel conductance, autonomic input, body temperature, and clock-regulated gene expression are often treated as fixed parameters or time-invariant inputs, causing simulated cardiac cells to correspond to an implicit and potentially arbitrary biological phase. In vivo, however, these factors...