Diagnostic and mechanistic insights from molecular profiling of explanted stereo-EEG depth electrodes

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24 Oct 2026 0 comments

Epilepsy surgery involving deep brain stereo-electroencephalography (SEEG) offers a unique window into the biology of epilepsy in living humans. Explanted SEEG electrodes retain nucleic acids, enabling identification of somatic variants underlying treatment-resistant epilepsies. Recent studies show SEEG depth electrodes also preserve trace material sufficient for high-quality, region-specific transcriptomic and epigenetic profiling at near-contact resolution, distinguishing seizure onset,...