Immunometabolic synaptopathy: linking metabolic syndrome to epileptogenesis through trained immunity and parvalbumin interneuron vulnerability

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24 Oct 2026 0 comments

CONCLUSION: Immunometabolic synaptopathy integrates cross-context evidence into a testable hypothesis of metabolically associated seizure susceptibility. The complete pathway to spontaneous epilepsy has not been demonstrated end-to-end and requires longitudinal, cell- and pathway-specific validation.