Altered astrocyte morphology in pathogenic HEPACAM variants: a multipoint analysis and new machine learning framework for 3D Sholl analysis

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25 Oct 2026 0 comments

Astrocytes are morphologically complex glial cells that play critical roles in brain development and function. Altered astrocyte morphology is associated with altered astrocyte function and is a common feature of many neurological disorders. Astrocytes express numerous membrane proteins that are important for their morphogenesis, including hepaCAM, an astrocyte-enriched cell adhesion molecule that regulates astrocyte branching organization, tiling, and coupling. Pathogenic variants of HEPACAM...