YAP Fuels Cerebral Cavernous Malformations by Regulating KLF4 Transcriptional Activity and Protein Stability

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25 Oct 2026 0 comments

Cerebral cavernous malformations (CCMs), which frequently predispose patients to strokes or seizures, primarily arise from endothelial specific loss-of-function mutations in the CCM genes, and occasionally accompanied by gain-of-function mutations in PIK3CA and MAP3K3. While the Hippo pathway is a well-established regulator of tissue homeostasis, its emerging relevance in vascular pathology particularly its precise role in CCM pathogenesis remains poorly understood. In this study, we demonstrate...