Early-life prolonged hyperthermic seizures alter disease trajectory in the Scn1a(+/-)(tm1Kea) mouse model of Dravet syndrome

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25 Oct 2026 0 comments

Dravet syndrome (DS) is a catastrophic developmental and epileptic encephalopathy caused most often by de novo loss-of-function mutations in SCN1A, the gene encoding the alpha subunit of the voltage-gated sodium channel (Na(v)1.1). Animal models such as the Scn1a(+/-)^(tm1Kea) mouse display relevant DS phenotypes including sensitivity to hyperthermia-induced seizures and later-life spontaneous seizures. Elevating the body temperature of immature Scn1a(+/-)^(tm1Kea) mice reliably triggers...