Creb1 aggravates glutamate-induced excitotoxicity and KA-induced seizure activity by transcriptionally activating Timp1

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26 Oct 2026 0 comments

Epilepsy is a chronic neurological disorder, more common in children and the elderly. Although treatments have advanced, significant challenges remain. This study focuses on its molecular mechanisms to provide new insights and strategies for its treatment. Gene expression omnibus (GEO) database analysis, enrichment analysis, and the establishment of protein-protein interaction (PPI) networks were conducted for gene screening. HT-22 cells were treated with glutamate (Glu) to establish an in vitro...