Pseudohyponatremia Caused by an Intravenously Administered Liposome Drug Product in a 1-Month Nonclinical Toxicity Study in Cynomolgus Monkeys

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27 Oct 2026 0 comments

Pseudohyponatremia is a laboratory artifact whereby measured serum sodium concentration is falsely low, despite normal plasma osmolality and sodium concentration in plasma water. This occurs when sodium is measured by indirect ion-selective electrode (ISE) methods on samples with hyperlipidemia or hyperproteinemia. In contrast, hyponatremia (low serum sodium concentration with hypotonic serum) is a potentially life-threatening electrolyte disturbance that can cause severe neurologic symptoms,...