Hemimegalencephaly in Children: A Systematic Review of Diagnosis, Management, and Outcomes in 161 Reported Cases

Aggregator

27 Oct 2026 0 comments

CONCLUSIONS: Hemimegalencephaly presents with a wide clinical and genetic spectrum and frequently results in drug-resistant epilepsy and developmental impairment. Although surgery may offer seizure relief, outcomes vary and the optimal approach remains individualized. Early diagnosis is essential to enable timely intervention and coordinated care. A multidisciplinary team including neurology, genetics, radiology and neurosurgery is key to optimizing outcomes. Broader studies including milder...