Inhibition of miR-206 Ameliorates Seizures and Cognitive Deficits via BDNF/TrkB Signaling in Pilocarpine-Induced TLE Mice

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27 Oct 2026 0 comments

Objectives: Temporal lobe epilepsy (TLE) causes spontaneous seizures, hippocampal neuronal loss, and cognitive impairment. This study investigated whether miR-206 inhibition attenuates seizures and cognitive dysfunction by activating the BDNF/TrkB cascade in mice with pilocarpine-induced TLE. Methods: Fifty TLE-model C57BL/6N mice were divided into five groups. MiR-206 antagomir or a negative control was stereotaxically injected into the hippocampus. ANA-12, a TrkB inhibitor, was given...